| Player | Pos | Team | Run Yds | Pass Yds | Rec Yds | Total Yds | Run TDs | Pass TDs | Rec TDs | K & PR TD | Total TDs | FF Pts | Used |
| Michael Vick | QB | Atl | 119 | 82 | 2 | 203 | - | 2 | - | - | 2 | 323 | 3 |
| Warrick Dunn | RB | Atl | 142 | 2 | 2 | 146 | 2 | - | - | - | 2 | 266 | 3 |
| Peyton Manning | QB | Ind | 7 | 238 | - | 245 | - | - | - | - | - | 245 | 4 |
| Edgerrin James | RB | Ind | 39 | - | 69 | 108 | - | - | - | - | - | 108 | 1 |
| Marvin Harrison | RC | Ind | - | - | 44 | 44 | - | - | - | - | - | 44 | 5 |
| Reggie Wayne | RC | Ind | - | - | 35 | 35 | - | - | - | - | - | 35 | 1 |
| Daunte Culpepper | QB | Min | 25 | 316 | - | 341 | 1 | 1 | - | - | 2 | 461 | 2 |
| Randy Moss | RC | Min | - | - | 51 | 51 | - | - | - | - | - | 51 | 2 |
| Tom Brady | QB | NE | 6 | 144 | - | 150 | 1 | 1 | - | - | 2 | 270 | 2 |
| Corey Dillon | RB | NE | 144 | - | 7 | 151 | - | - | - | - | - | 151 | 7 |
| Chad Pennington | QB | NYJ | 3 | 182 | - | 185 | - | - | - | - | - | 185 | 1 |
| Curtis Martin | RB | NYJ | 77 | - | - | 77 | - | - | - | - | - | 77 | 1 |
| Donovan McNabb | QB | Phi | 3 | 286 | - | 289 | - | 2 | - | - | 2 | 409 | 2 |
| Brian Westbrook | RB | Phi | 70 | - | 47 | 117 | - | - | 1 | - | 1 | 177 | 6 |
| Jerome Bettis | RB | Pit | 101 | - | 21 | 122 | 1 | - | - | - | 1 | 182 | 1 |
| Marc Bulger | QB | Stl | 4 | 299 | - | 303 | - | 2 | - | - | 2 | 423 | 5 |
| Torry Holt | RC | Stl | - | - | 42 | 42 | - | - | 1 | - | 1 | 102 | 11 |