| Player | Pos | Team | Run Yds | Pass Yds | Rec Yds | Total Yds | Run TDs | Pass TDs | Rec TDs | K & PR TD | Total TDs | FF Pts | Used |
| Jake Plummer | QB | Den | - | 284 | - | 284 | - | 2 | - | - | 2 | 404 | 1 |
| Tatum Bell | RB | Den | 49 | - | 32 | 81 | 1 | - | - | - | 1 | 141 | 1 |
| Rod Smith | RC | Den | - | - | 99 | 99 | - | - | 1 | - | 1 | 159 | 1 |
| Brett Favre | QB | GB | 7 | 216 | - | 223 | - | 1 | - | - | 1 | 283 | 5 |
| Ahman Green | RB | GB | 80 | - | 16 | 96 | - | - | - | - | - | 96 | 1 |
| Donald Driver | RC | GB | - | - | 78 | 78 | - | - | - | - | - | 78 | 1 |
| Javon Walker | RC | GB | - | - | 27 | 27 | - | - | - | - | - | 27 | 5 |
| Peyton Manning | QB | Ind | 1 | 457 | - | 458 | 1 | 4 | - | - | 5 | 758 | 4 |
| Edgerrin James | RB | Ind | 63 | - | 11 | 74 | 1 | - | - | - | 1 | 134 | 1 |
| Brandon Stokely | RC | Ind | - | - | 33 | 33 | - | - | - | - | - | 33 | 1 |
| Marvin Harrison | RC | Ind | - | - | 50 | 50 | - | - | - | - | - | 50 | 1 |
| Daunte Culpepper | QB | Min | 54 | 284 | - | 338 | - | 4 | - | - | 4 | 578 | 14 |
| Michael Bennett | RB | Min | 31 | - | 12 | 43 | - | - | - | - | - | 43 | 1 |
| Nate Burleson | RC | Min | - | - | 60 | 60 | - | - | 1 | - | 1 | 120 | 2 |
| Randy Moss | RC | Min | - | - | 70 | 70 | - | - | 2 | - | 2 | 190 | 14 |
| Curtis Martin | RB | NYJ | 66 | - | 47 | 113 | - | - | - | - | - | 113 | 5 |
| Drew Brees | QB | SD | 17 | 319 | - | 336 | - | 2 | - | - | 2 | 456 | 2 |
| LaDainian Tomlinson | RB | SD | 80 | - | 53 | 133 | - | - | - | - | - | 133 | 4 |
| Antonio Gates | RC | SD | - | - | 89 | 89 | - | - | 1 | - | 1 | 149 | 2 |
| Shaun Alexander | RB | Sea | 40 | - | 25 | 65 | - | - | - | - | - | 65 | 15 |
| Marc Bulger | QB | Stl | 10 | 313 | - | 323 | - | 2 | - | - | 2 | 443 | 4 |
| Steven Jackson | RB | Stl | 36 | - | (2) | 34 | - | - | - | - | - | 34 | 2 |
| Torry Holt | RC | Stl | - | - | 108 | 108 | - | - | 1 | - | 1 | 168 | 3 |