| Player | Pos | Team | Run Yds | Pass Yds | Rec Yds | Total Yds | Run TDs | Pass TDs | Rec TDs | K & PR TD | Total TDs | FF Pts | Used |
| Tom Brady | QB | NE | 3 | 280 | - | 283 | - | 2 | - | - | 2 | 403 | 4 |
| Drew Brees | QB | NO | (2) | 243 | - | 241 | - | 1 | - | - | 1 | 301 | 5 |
| Jeff Garcia | QB | Phi | 9 | 240 | - | 249 | - | 1 | - | - | 1 | 309 | 1 |
| Philip Rivers | QB | SD | 3 | 230 | - | 233 | - | - | - | - | - | 233 | 1 |
| Peyton Manning | QB | Ind | 5 | 170 | - | 175 | - | - | - | - | - | 175 | 2 |
| Brian Westbrook | RB | Phi | 116 | - | 5 | 121 | 2 | - | - | - | 2 | 241 | 8 |
| LaDainian Tomlinson | RB | SD | 123 | - | 64 | 187 | 2 | - | - | - | 2 | 307 | 2 |
| Shaun Alexander | RB | Sea | 108 | - | 12 | 120 | 2 | - | - | - | 2 | 240 | 2 |
| Jamal Lewis | RB | Bal | 53 | - | 24 | 77 | - | - | - | - | - | 77 | 1 |
| Marques Colston | WR | NO | - | - | 55 | 55 | - | - | - | - | - | 55 | 2 |
| Reggie Brown | WR | Phi | - | - | 76 | 76 | - | - | - | - | - | 76 | 1 |
| Muhsin Muhammad | WR | Chi | - | - | 38 | 38 | - | - | - | - | - | 38 | 1 |
| Marvin Harrison | WR | Ind | - | - | 45 | 45 | - | - | - | - | - | 45 | 2 |
| Bernard Berrian | WR | Chi | - | - | 105 | 105 | - | - | 1 | - | 1 | 165 | 1 |
| Reggie Wayne | WR | Ind | - | - | 51 | 51 | - | - | - | - | - | 51 | 3 |
| Antonio Gates | TE | SD | - | - | 61 | 61 | - | - | - | - | - | 61 | 1 |
| Mark Clayton | WR | Bal | - | - | 73 | 73 | - | - | - | - | - | 73 | 1 |
| Reche Caldwell | WR | NE | - | - | 80 | 80 | - | - | 1 | - | 1 | 140 | 1 |